Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

721
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
721
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

172
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
172
Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

126
Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
126
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

352
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
352

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Revisiting guidelines for global plastic and reconstructive surgical initiatives: Recommendations from a scoping review of two decades of published evidence.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Unintended consequences of the 505(b)(2) regulatory pathway for health systems.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same author

The Cost of Holding the Blade: Socioeconomic Barriers in US Surgical Training.

The Journal of surgical research·2026
Same author

A Decade Later: An Updated Systematic Review and Meta-analysis of Overall Survival, Disease-Free Survival, Local Recurrence, and Nipple-Areolar Recurrence Following Nipple-Sparing Mastectomy.

Annals of surgical oncology·2026
Same author

Benzodiazepine Tapering: Evidence Limitations and Research Recommendations.

Journal of addiction medicine·2026
Same author

Resource management and clinical outcomes during a national intravenous fluid shortage.

Journal of hospital medicine·2026

相关实验视频

Updated: Jun 25, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K

空的代码车:药物短缺随着时间的推移.

Tyler Gentile1, Isabel Snee1, Dorothy Heinrichs2

  • 1Georgetown University School of Medicine, Washington, DC, USA.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
|May 27, 2024
PubMed
概括
此摘要是机器生成的。

基本代码车药物的药物短缺频繁且持续,影响了患者的护理. 改善药物供应链对于患者安全和紧急情况下的一致治疗至关重要.

关键词:
代码购物车药物药物药物药物短缺 药物的短缺药物的安全性 药物的安全性供应链供应链供应链供应链.

更多相关视频

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

4.6K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

12.9K

相关实验视频

Last Updated: Jun 25, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

4.6K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

12.9K

科学领域:

  • 药理学 药理学是指药理学的学科.
  • 医疗保健服务研究 医疗服务研究
  • 供应链管理 供应链管理

背景情况:

  • 临床医生依赖于在密码车里随时可用的药物,用于关键护理情况,如心脏骤停.
  • 确保及时和准确的药物治疗依赖于这些必需药物的持续储存.

研究的目的:

  • 分析药物短缺的趋势,这些药物通常储存在医院代码车里.
  • 描述这些关键药物短缺的频率,持续时间和原因.

主要方法:

  • 利用来自犹他大学药物信息服务 (UUDIS) 的药物短缺数据,涵盖2001年至2022年.
  • 提取并分析了关于缺乏的数量,持续时间,药物特征和报告的原因的信息.

主要成果:

  • 在2001年至2022年期间,报告了71起代码车药物短缺事件,在2010年达到顶峰.
  • 解决的短缺平均为18.2个月;乳糖,化和氨酸注射经历了显著的长期短缺.
  • 制造延迟是最常见的短缺原因,主要药物的供应商有限,如先填注射器.

结论:

  • 对于代码车药物来说,经常和长期的药物短缺对患者的护理构成重大风险.
  • 制定机构缓解策略和加强药物供应链对于患者安全和提供优质医疗保健至关重要.