印刷后固化时间对直接打印对齐剂的细胞毒性的影响:试点研究
Giorgio Iodice1, Bjorn Ludwig2, Elena Polishchuk3
1Department of Dental and Maxillo-Facial Sciences, Section of Orthodontics and Gnathology, University of Naples "Federico II", Naples, Italy.
Orthodontics & craniofacial research
|May 27, 2024
概括
3D打印的正统牙对齐器的固化时间会影响其细胞毒性. 较长的固化时间增加了对人类牙纤维细胞的细胞毒性作用,类似于传统的对齐器.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 矯正牙科 矯正牙科是一種矯正牙科.
背景情况:
- 3D打印越来越多地用于正义牙对齐器的制造.
- 这些3D打印对齐剂的细胞毒性需要彻底调查.
- 固化时间是3D打印中的关键参数,可能会影响材料特性和生物相互作用.
研究的目的:
- 根据不同的固化时间,评估3D打印的正牙对齐器的体外细胞毒性.
- 为了比较3D打印对齐器与传统热成型对齐器的细胞毒性.
- 确定3D打印对齐器材料的固化时间和细胞毒性潜力之间的关系.
主要方法:
- 60个3D打印的对齐器样本 (Tera Harz TC-85 DAC树脂) 被分为三个固化时间组 (14,24,50分钟).
- 赞杜拉FLX对齐器作为对照组.
- 人类牙纤维细胞 (HGF-1) 用于通过样本和唾液化后的细胞活力测试来评估细胞毒性.
主要成果:
- 与玻璃对照相比,50分钟的固化时间显著减少了纤维细胞生长.
- 在增长的固化时间和纤维细胞生长之间观察到负线性趋势.
- 所有测试的对齐器样本,包括对照样本,在暴露于唾液时显示纤维细胞活力降低.
结论:
- 直接3D打印的正统牙对齐器具有与传统热成型对齐器相比的细胞毒性.
- 治愈时间和细胞毒性之间存在直接的相关性,更长的治愈时间可能会增加不良影响.
- 遵守严格的制造协议,特别是关于固化时间,对于最大限度地减少3D打印对齐器的细胞毒性潜力至关重要.
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