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Updated: Jun 25, 2025

Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay
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Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay

Published on: February 3, 2022

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时间和PARP1的相互作用抑制了与复制相关的DNA差距积累

Joanne Saldanha1,2, Julie Rageul1, Jinal A Patel1

  • 1Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

Nucleic acids research
|May 27, 2024
PubMed
概括

无时间 (TIM) 蛋白质对于协调DNA复制至关重要,它通过确保正确的Okazaki片段处理和限制DNA缺口来协调DNA复制. 它与PARP1的相互作用对DNA修复至关重要,是潜在的癌症治疗点.

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