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免疫检查点抑制剂:癌症治疗中的突破

Xueqing Kong¹, Jinyi Zhang¹, Shuwei Chen¹

¹Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Cancer biology & medicine

|May 27, 2024

概括

使用单克隆抗体 (mAbs) 的免疫检查点封锁 (ICB) 对癌症治疗有希望,但面临阻力. 研究正在探索新的免疫检查点目标,如TIGIT和LAG-3,以提高有效性.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

免疫疗法,特别是免疫检查点封锁 (ICB),在过去二十年中成为癌症治疗的基石.
针对CTLA-4和PD-1/PD-L1等免疫检查点的单克隆抗体 (mAbs) 在各种固体瘤中取得了显著的临床成功.
一个主要的挑战仍然存在:由于瘤免疫逃避,大量患者对当前的ICI产生抵抗或耐受性.

研究的目的:

审查已建立和新型免疫检查点抑制剂 (ICI) 的结构和临床进展.
讨论mAbs针对新发现的免疫检查点分子的潜在应用.
突出克服当前免疫疗法耐药性的策略.

主要方法:

关于免疫检查点阻塞疗法的现有文献的审查.
对已批准和正在研究的ICI进行临床试验数据的分析.
讨论各种免疫检查点目标的分子结构和功能.

主要成果:

已建立的ICI (抗CTLA-4,抗PD-1,抗PD-L1) 已经证明了临床可行性,但受到治疗耐药性的限制.
新兴的免疫检查点目标包括TIGIT,TIM-3,LAG-3,VISTA,BTLA和SIRPα,功能性mAbs正在开发中.
这些新的目标为协同疗法提供了潜在的潜力,以增强抗癌免疫反应.

结论:

克服对ICB的耐药性对于改善癌症免疫治疗患者的治疗结果至关重要.
针对新的免疫检查点是开发下一代癌症治疗的有希望的途径.
需要对这些新型ICI的结构和临床应用进行进一步的研究.

关键词:

在 CTLA-4 中.国际投资机构 (ICI) 是国际投资机构 (ICI) 的一个组成部分.免疫治疗是一种免疫疗法.在PD-1中使用PD-1.癌症癌症癌症癌症癌症

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