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患有风险和明显的双相情感障碍的个体中较大的门
Florian Thomas-Odenthal1,2, Frederike Stein1,2, Christoph Vogelbacher2,3
1Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg, Germany.
Psychological medicine
|May 27, 2024
概括
患有双相情感障碍 (BD) 风险的个人和被诊断出患有双相情感障碍的患者共享灰色质变化,特别是在右上. 这些大脑变化可能表明BD发展的脆弱性标志物.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 大脑解剖学 大脑解剖学
背景情况:
- 患双相情感障碍 (BD) 风险的个体表现出遗传和非遗传风险因素.
- 尚不清楚有风险的个体和被诊断为BD患者是否有类似的灰质大脑变化.
研究的目的:
- 与健康对照人群相比,研究患有BD风险的个体和被诊断为BD患者之间的共享灰质体积差异.
- 为了识别BD的潜在神经解剖学脆弱性标志物.
主要方法:
- 基于voxel的形态测量 (3TMRI) 用于比较410名参与者的灰质体积 (208名风险患者,87名BD患者,115名对照).
- 结合分析发现了风险人群和BD患者之间灰质变化的相似之处.
- 来自七个成像站点的数据使用ComBat.Bat进行了协调.
主要成果:
- 与对照人群相比,风险人群和BD患者都显示出较大的右膜体积.
- 处于危险阶段的个体有较小的右下尾回形体积.
- 与对照组相比,BD患者表现出较大的左前皮质体积.
结论:
- 右门的变化可以作为双相情感障碍 (BD) 的脆弱性标志物.
- 这些发现有助于理解BD风险和发展的神经生物学基础.
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