FGF21调解了对饮食中巨量营养素的性别依赖反应
Karla A Soto Sauza1, Karen K Ryan1
1Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA.
The Journal of clinical endocrinology and metabolism
|May 27, 2024
概括
性影响身体组成和脂肪代谢. 纤维细胞生长因子-21 (FGF21) 在这些取决于性别的代谢差异中起作用,在男性和女性中不同影响脂肪和肌肉质量保存.
科学领域:
- 代谢生理学 代谢生理学
- 内分泌学 在内分泌学.
- 身体构成研究 身体构成研究
背景情况:
- 性别是身体组成和基质利用的关键决定因素.
- 雌性通常表现出更大的脂肪和抵抗脂肪的调动,而雄性拥有更多的瘦质量和容易调动脂肪.
- 了解这些取决于性别的差异背后的机制对于代谢和生殖健康至关重要.
研究的目的:
- 为了研究肝素纤维细胞生长因子-21 (FGF21) 在调解性别特异性代谢反应中的作用.
- 检查FGF21如何影响身体组成和基质利用以性别依赖的方式.
- 评估营养状况对男性和女性FGF21分泌和作用的影响.
主要方法:
- 关于代谢和FGF21的性别差异现有文献的综述21.
- 与性别相关的药理FGF21管理数据的分析.
- 在不同营养条件下检查内源性FGF21分泌物 (能量过剩与限制).
主要成果:
- 药物学FGF21的使用引起了性别偏差的效应:男性保留肌肉质量 (增加脂质代谢),而女性保留脂肪质量 (减少肌肉质量),当能量充足时.
- 与雌性相比,雄性在休息状态期间对宏观营养素失衡的反应中表现出更大的FGF21分泌.
- 在能量限制条件下,性别对FGF21分泌和代谢行为的影响可能会逆转.
结论:
- 纤维细胞生长因子-21 (FGF21) 是一个合理的机制链接,有助于依赖性调节脂质储存和调动.
- 需要进一步的研究来充分阐明性别,FGF21和对营养变化的代谢适应之间的复杂相互作用.
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