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使用NRPS工程对Odilorhabdin生物合成基因集群的调查NRPS工程

Leonard Präve1,2, Carsten E Seyfert3,4, Kenan A J Bozhüyük1,2,5,6

  • 1Max-Planck-Institute for Terrestrial Microbiology, Department of Natural Products in Organismic Interactions, 35043, Marburg, Germany.

Angewandte Chemie (International ed. in English)
|May 27, 2024
PubMed
概括

研究人员通过非核糖体合成酶 (NRPS) 工程阐明了抗生素NOSO-95A的生物合成. 这项工作揭示了新的生物合成原理和奥迪洛拉卜丁的前药激活机制.

关键词:
基酶的功能是基酶.自然产品是一种自然产品.非核糖体合成酶工程非核糖体合成酶工程类抗生素是一种抗生素.支持毒品的支持者.

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Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...