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Updated: Jun 25, 2025

Polymeric Microneedle Array Fabrication by Photolithography
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Polymeric Microneedle Array Fabrication by Photolithography

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一个多功能的冷针贴片用于可追溯的光动力疗法.

Yashi Li1, Xingxing Li1, Gang He1

  • 1Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.

Advanced materials (Deerfield Beach, Fla.)
|May 27, 2024
PubMed
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此摘要是机器生成的。

一种新型的冷针贴片为可追溯光动力学疗法 (PDT) 提供光敏剂,增强瘤氧气水平并提高治疗效率,降低毒性.

科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术 纳米技术
  • 光动力学疗法 光动力学疗法

背景情况:

  • 光动力学疗法 (PDT) 面临着诸多挑战,包括缺乏光敏剂,缺乏成像指导和瘤微环境问题.
  • 需要有效的策略来改善光敏感剂的稳定性,生物可用性和PDT的治疗结果.

研究的目的:

  • 为增强光动力学治疗 (PDT) 开发可追溯的冷针贴片 (CMN-CCPH).
  • 为了改善光敏剂的保存,输送和瘤氧化,以增强治疗疗效.

主要方法:

  • 制造一个装有甲酶生物矿物化铜纳米花 (CCP NFs) 含有血甲乙烯 (HMME) 的冷针贴片 (CMN).
  • 在CMN-CCPH内对60天内HMME和触酶稳定性的评估.
  • 在体内评估使用光 (FL) /光声学 (PA) 成像来监测HMME分布和氧和 (sO2).
  • 对瘤消除和全身毒性治疗疗效的评估.

主要成果:

  • 在CMN-CCPH中,HMME和catalase的生物活性维持了60多天,从而提高了生物可用性.
  • catalase诱导的氧气生成和Cu2+介导的谷氨耗尽改善了PDT的疗效.
  • 实时FL/PA成像证实了内HMME和氧气丰富,降低了全身毒性.
关键词:
生物模拟矿物化的生物模拟矿物化冰冷微粒针补丁补丁 冰冷微粒针补丁黑色素瘤是一种黑色素瘤.可追溯的光动力疗法可以追溯.瘤微环境是一个微环境.

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  • 在CMN-CCPH治疗中观察到显著的瘤消除.

    • 结论:

    • 开发的CMN-CCPH是可追溯PDT的多功能平台,克服了关键的治疗障碍.
    • 这种方法通过改善药物输送,氧气生成和实时监测,显著提高PDT的疗效.
    • 该CMN-CCPH显示了在癌症治疗中临床转化有前途的潜力.