纤维细胞生长因子21通过调节海马体L-乳酸盐平衡来提高小鼠的学习和记忆性能
Jiaojiao Xie1, Jiapin Yan1, Keru Ji1
1State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
International journal of biological macromolecules
|May 27, 2024
概括
纤维细胞生长因子21 (FGF21) 通过提高L-乳酸盐利用率来改善大脑功能. 这种代谢重编程可以防止神经元损伤,并恢复小鼠的认知表现.
科学领域:
- 神经科学是一个神经科学.
- 代谢生物学代谢生物学
- 生物化学 生化学
背景情况:
- 纤维细胞生长因子21 (FGF21) 调节葡萄糖和脂质代谢.
- FGF21在L-乳酸盐平衡和大脑功能中的作用尚不清楚.
研究的目的:
- 为了研究FGF21对大脑L-乳酸盐平衡的作用.
- 阐明FGF21对神经元代谢和功能作用的潜在机制.
主要方法:
- 使用小鼠模型进行L-乳酸盐和FGF21治疗.
- 采用基于核磁共振的代谢学来分析大脑代谢物.
- 评估了参与L-乳酸盐平衡和神经元功能的关键蛋白质.
主要成果:
- L-乳酸盐的积累损害了学习,记忆和神经元的生物能量,增加了氧化应激和亡.
- FGF21治疗逆转了这些缺陷,增强了海马神经元中L-乳酸盐的吸收和利用.
- 证明FGF21促进L-乳酸盐-酸盐流动,保持神经元能量和氧化还原平衡.
结论:
- 维持L-乳酸盐-酸盐的流量对于神经元的生物能量和氧化还原稳定至关重要.
- 通过优化L-乳酸盐利用,FGF21保护大脑免受代谢压力.
- FGF21促进新陈代谢重编程,防止高L-乳酸盐可用性期间的神经元脆弱性.
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