水触发的形状记忆纤维素/藻酸盐/蒙莫里隆石复合海绵,用于快速静血
Yeying Liu1, Xiangfei Yin1, Yinchun Hu1
1Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China.
International journal of biological macromolecules
|May 27, 2024
概括
一种新型的水触发形状记忆复合血静海绵 (CNSAMMTCa) 已开发用于快速伤口愈合. 这种先进的材料有效地促进了血液凝固,为临床血静提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 血液静止 血液静止 血液静止
背景情况:
- 严重创伤造成的无法控制的出血会对生命构成重大威胁.
- 开发有效的静血材料以快速治疗伤口至关重要.
研究的目的:
- 为了准备一个水触发形状记忆的碳氧化纤维素纳米纤维/藻酸盐/蒙莫里隆石 (CNSAMMTCa) 复合血静海绵.
- 通过促进血液凝结和激活内在通路来评估其静血疗效.
主要方法:
- 使用定向冷干燥技术,创建了一个异构的三维多孔结构.
- 复合海绵的多孔结构,吸水能力,细胞相容性和血液细胞聚合能力的特征.
- 在体内评估使用小鼠审查出血和肝破裂出血模型.
主要成果:
- CNSAMMTCa复合海绵表现出可取的多孔结构,优良的吸水能力和良好的细胞相容性.
- 该材料显示出显著的血细胞聚合能力.
- 在两种出血模型中,CNSA3MMT2Ca配方显示出优异的凝血性能.
结论:
- CNSAMMTCa复合静血海绵是一种安全高效的材料,用于快速静血.
- 开发的静血海绵显示出作为替代临床静血材料的潜力.
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