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哈尔齐亚诺利德B-G:未经描述的从Trichoderma harzianum ZN-4真菌中分离出来的布丁诺利德

Chengzeng Zhou¹, Yichao Ge¹, Donghe Lan¹

¹Ocean College, Zhejiang University, Zhoushan 316000, China.

|May 27, 2024

概括

研究人员发现了来自Trichoderma harzianum真菌的五种新型的玛-丁烯酸,harzianolides BF. 化合物1表现出独特的结构,并与另一种化合物一起,显示对真菌Pestalotiopsis theae.ae的活性.

科学领域:

自然产品化学化学
菌类学菌类学是指菌类学.
有机化学有机化学

背景情况:

海洋衍生真菌是新型生物活性化合物的丰富来源.
众所周知,Trichoderma harzianum可以产生各种具有不同生物活动的二次代谢产物.
沿海沉积物有独特的微生物群落,有可能发现新的化学实体.

研究的目的:

从Trichoderma harzianum ZN-4真菌中分离和鉴定新的玛-丁烯酸.
用光谱方法和计算计算来阐明孤立化合物的结构.
为了评估与植物病原菌的隔离化合物的生物活性.

主要方法:

在Trichoderma harzianum ZN-4的液体发酵中.
使用色谱技术提取和分离化合物 (例如EtOAc提取,列色谱).
通过核磁共振 (NMR) 光谱学,质谱学 (MS) 和电子循环二元化 (ECD) 量子化学计算来阐明结构.

主要成果:

鉴定出了五种新的玛-丁烯,被指定为harzianolides BF (1-5),以及一种前体harzianolide G (6).
化合物1具有一个不寻常的碳骨架,具有甲桥接的环.
化合物1和7对Pestalotiopsis theae表现出抑制活性,最小抑制度 (MIC) 值分别为25和50μg/mL.

结论:

这项研究成功地从一种海洋衍生的真菌中分离和特征化了新型的玛-丁烯酸菌.
化合物1代表了玛-丁烯酸乳类中独特的化学结构.
孤立的化合物,特别是1和7,显示出对Pestalotiopsis theae的抗真菌剂的潜力,需要进一步调查.

关键词:

它具有抗真菌活性,具有抗真菌活性.基化物 (Butenolides) 是一种基化物在 ECD 计算中使用 ECD 计算.二次代谢产物二次代谢产物三皮虫 (Trichoderma harzianum) 是一种有毒的动物.

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