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沈迈注射对环素诱导心脏毒性的影响:系统性审查和元分析

Lili Yang¹, Xiaorui Liu¹, Wen Yang¹

¹School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Complementary therapies in medicine

|May 27, 2024

概括

沈迈注射通过改善心脏功能的标志物,显示出在治疗环素诱导的心脏毒性的前景. 然而,需要进一步的高质量试验来确认其有效性和安全性.

科学领域:

心脏病学心脏病学
药理学药理学是指药理学的学科.
在瘤学瘤学.

背景情况:

抗环素化疗可以引起心脏毒性,这是一个重大的临床问题.
沈迈注射,一种传统的草药,经常被认为是管理这种副作用.

研究的目的:

系统地评估Shenmai注射在治疗反环素诱导心脏毒性的疗效和安全性.
综合这种治疗干预的随机对照试验 (RCT) 的证据.

主要方法:

在8个数据库和2个临床试验注册表中进行了全面的文献搜索,截至2023年7月1日.
用RStudio和RevMan 5.4.4进行了涉及2140名患者的16个RCT的元分析.
用GRADE系统来评估证据的质量.

主要成果:

沈迈注射显著改善了ST-T段变化,肌酸激酶,肌酸激酶异酶,延长QT间隔,低QRS电压,鼻动心,心房早跳和心室早收缩.
没有观察到左心室喷射率或心房塞的显著改善.
在包含的研究中没有报告Shenmai注射的安全数据.
证据质量从非常低到中等不等.

结论:

沈迈注射证明了在管理antracycline诱导心脏毒性的特定方面具有潜在的有效性.
目前的证据受限于现有的RCT的方法质量.
建议进行高质量的大规模临床试验,以验证这些发现并评估安全性.

关键词:

人类循环类药物.心脏毒性有关心脏的毒性.有效性有效性.安全的安全的安全的安全的安全.沈迈注射的注射方式

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