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在淡水中具有耐药性的藻类繁殖:Microcystis和抗生素耐药性基因之间的潜在相互作用

Wenhui Ji¹, Jingkai Ma¹, Zhipeng Zheng¹

¹Shanghai Engineering Research Center of Biotransformation of Organic Solid Waste, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, China; Key Laboratory of Northwest Water Resource, Environment and Ecology, MOE, Xi'an University of Architecture and Technology, Xi'an 710055, China; Chongqing Key Laboratory of Precision Optics, Chongqing Institute of East China Normal University, Chongqing 401120, China.

The Science of the total environment

|May 27, 2024

概括

由微囊 (MCs) 驱动的微囊繁殖,通过改变微生物群落和增加DNA损伤来促进抗生素耐药性基因 (ARG) 的传播. 控制微囊是减少水生环境中ARG的关键.

科学领域:

环境微生物学环境微生物学
水生生态学水生生态学
公共卫生公共卫生

背景情况:

全球微囊 (Microcystis) 繁殖的增加,一种产生微囊 (MCs) 的蓝藻细菌.
新出现的证据将微囊与抗生素耐药性基因 (ARG) 的扩散联系起来.
微囊 (MCs) 是一种强有力的毒素,影响细胞过程,并可能驱动ARG传播.

研究的目的:

系统地组织Microcystis影响水性ARG传播的机制.
确定有关MCs对细菌电子运输链和水平基因转移 (HGT) 的影响的知识差距.
探索Microcystis藻类聚合物的作用,作为ARG保存和转移的热点.

主要方法:

这是一份对大约150项近期研究的综合性综述.
分析MCs的生化作用 (蛋白质酸酶抑制,ROS诱导).
检查微囊对微生物群落结构和ARG动态的影响.

主要成果:

在开花期间MCs和微生物结构的波动显著影响水borneARGs.
MCs诱导氧化应激和DNA损伤,为ARG产生选择性压力.
微囊聚合物作为ARG保存和转移的热点,尽管营养竞争可以限制携带ARG的细菌.

结论:

微囊的开花是通过直接和间接机制传播ARG的一个重要因素.
需要进一步研究MCs的特定分子相互作用和Microcystis在HGT中的作用.
有效控制微囊的开花对于缓解ARG传播至关重要,建筑湿地和光催化剂显示出希望.

关键词:

抗生素耐药性抗生素耐药性细菌社区的细菌社区淡水体中的淡水体.微囊是一种微囊.微囊的开花微囊的开花

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