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艾滋病毒治疗中的补充和替代医学:使用频率,风险和与抗逆转录病毒疗法的相互作用
Elena Colominas-González1,2, Marta De Antonio1, Montserrat Masip3
1Pharmacy Department, Hospital del Mar, Barcelona, Spain.
概括
几乎一半的艾滋病毒感染者使用补充和替代医学 (CAM). 虽然CAM的使用没有影响抗逆转录病毒治疗 (ART) 的坚持或疗效,但许多患者面临着与ART的潜在药物相互作用.
科学领域:
- 综合医学是一个整体的医学.
- 艾滋病毒/艾滋病药物治疗药物治疗
- 药物相互作用 药物相互作用
背景情况:
- 艾滋病毒感染者 (PLWH) 经常使用补充和替代医学 (CAM).
- 了解CAM使用模式和潜在的相互作用对于管理HIV治疗至关重要.
- 抗逆转录病毒疗法 (ART) 的坚持和有效性可能会受到同时使用CAM的影响.
研究的目的:
- 确定CAM天然产品在大量PLWH群体中的使用频率和模式.
- 为了确定CAM和ART之间的潜在药物相互作用 (DDI).
- 评估CAM使用对ART坚持和有效性的影响.
主要方法:
- 在西班牙医院中对420名PLWH进行了横截面,多中心的调查.
- 面对面调查问卷收集了关于CAM消费,社会人口统计和临床信息的数据.
- 使用利物浦大学数据库识别了CAM-ARTDDI;评估了患者因素.
主要成果:
- 49.8%的参与者使用至少一种CAM产品;常见产品包括茶,生,鱼油和大麻.
- 使用CAM与基于整合酶抑制剂的ART (OR 1.54) 有关.
- 在20.6%的CAM使用者中发现了50种潜在的CAM-ART相互作用,其中80%具有临床意义. 没有观察到对ART疗效或坚持的影响.
结论:
- 在PLWH中使用CAM是常见的,特别是那些使用整合酶抑制剂ART的人.
- 很大一部分患者有临床显著的CAM-ART相互作用的风险.
- 持续的药物审查对于监测PLWH中CAM使用至关重要.
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