循环中的高MIF水平表明与非典型的抗精神病药物诱导的代谢不良影响有关
Xi Chen1,2,3, Pingyi Gao2, Yadan Qi2
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Translational psychiatry
|May 27, 2024
概括
非典型的抗精神病药物增加了巨细胞迁移抑制因子 (MIF) 水平,与胰岛素抵抗和高胆固醇等代谢问题相关. 在精神分裂症患者中,MIF可以作为监测这些不良影响的标志物.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 非典型抗精神病药 (AAP) 对于精神分裂症 (SZ) 治疗至关重要,但会引起不良代谢效应.
- 这些由AAPs引起的代谢异常背后的机制尚未完全理解.
- 巨细胞迁移抑制因子 (MIF) 与炎症和代谢过程有关.
研究的目的:
- 调查巨细胞迁移抑制因子 (MIF) 与抗精神病药物诱导的代谢异常之间的关联.
- 在接受AAP治疗的精神分裂症患者中比较MIF水平和代谢概况,与典型抗精神病药物 (TAP) 和健康对照进行比较.
主要方法:
- 一项涉及142名健康个体和388名SZ患者 (接受TAP或AAP治疗) 的横截面研究,从2017-2020年开始.
- 使用正负综合征量表 (PANSS) 评估精神分裂症症状.
- 测量血MIF水平和代谢指数 (包括胰岛素耐药性,甘油三和总胆固醇).
主要成果:
- 与健康对照组相比,在接受五种主要AAP单一治疗的患者中观察到显著升高的血MIF水平 (p < 0.0001).
- 在接受TAP治疗的患者中,没有发现MIF水平的显著增加 (p > 0.05).
- 在AAP组中,MIF水平升高与胰岛素抵抗 (β=0.024,p=0.020),甘油三 (β=0.019,p=0.001) 和总胆固醇 (β=0.012,p=0.038) 有显著的相关性.
结论:
- 血MIF水平与非典型抗精神病药物诱导的代谢异常明显相关.
- MIF显示出作为监测与AAP治疗相关的不良代谢影响的特定生物标志物的潜力.
- 进一步的研究可以探索针对MIF的干预措施,以减轻抗精神病药物诱导的代谢功能障碍.
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