多壁碳纳米管表面功能纳米颗粒用于刺激响应的双重药物化合物输送
Masoumeh Nabitabar1, Maryam Shaterian2, Hossein Danafar3
1Chemistry Department, Faculty of Science, Zanjan University, Zanjan, Iran.
Scientific reports
|May 27, 2024
概括
这项研究开发了一种新型的碳纳米管输送系统,用于同时输送黄素和甲醇,提高癌症治疗效率,并减少副作用. 新配方在细胞系研究中显示出显著的抗癌活性和最小的毒性.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 碳纳米管 (CNT) 显示出在癌症治疗中药物输送的潜力.
- 同时提供黄素 (CUR) 和甲铁酸盐 (MTX) 提供更好的疗效和减少副作用.
- 基于专的纳米颗粒 (BSA-MTX) 用于增强CUR传递.
研究的目的:
- 开发和评估使用功能化的多壁碳纳米管 (ƒ-MWCNT) 共同输送CUR和MTX的新型药物输送系统的有效性.
- 为了评估CUR-MTX-BSA-CNT配方的物理和化学特性.
- 为了研究共同输送系统对癌症细胞系的体外细胞毒性和协同效应.
主要方法:
- 用MTX结合的蛋白纳米颗粒 (BSA-MTX) 的配方及其与CUR和 ƒ-MWCNT 的结合.
- 使用DLS,TEM,FTIR,UV/Vis,SEM和DSC进行表征.
- 在癌症细胞系 (例如,MCF-7) 上使用MTT试验进行体内细胞毒性评估.
- 使用蛋白酶K酶对药物释放和稳定性的评估.
主要成果:
- 这种 ƒ-MWCNT-CUR-BSA-MTX 配方证明了 CUR 和 MTX 的有效联合交付.
- 联合疗法对MCF-7乳腺癌细胞表现出协同作用.
- 这种新型的输送系统与单个成分相比显示出显著的抗癌活性,毒性最小.
- 鉴定证实了纳米配方的物理和化学完整性.
结论:
- ƒ-MWCNT-CUR-BSA-MTX在癌症治疗中作为CUR和MTX联合输送的有效载体.
- 这种组合策略对乳腺癌的预防和治疗都有希望.
- CNTs的独特特性,包括高表面积和药物载荷能力,使它们成为有针对性的药物输送和增强治疗效率的理想选择.
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