通过超声波对男性先天性上腺增生患者进行不孕症风险评估
Zhiqian Wang1,2, Ronghui Wang1, Xing Wang1
1Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 2nd Ruijin Road 197, Shanghai, 200025, People's Republic of China.
Scientific reports
|May 27, 2024
概括
在先天性上腺增生症 (CAH) 中,丸上腺休息瘤 (TART) 可能导致不孕. 超声波损伤评分有效地识别出高风险患有精子度和运动能力受损的患者,有助于保持生育能力.
科学领域:
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
- 生殖医学 生殖医学
背景情况:
- 丸上腺休息瘤 (TART) 是先天性上腺增生症 (CAH) 的常见并发症,导致性腺功能障碍和不孕症.
- 虽然早期的激素治疗至关重要,但过度的葡萄糖皮质激素治疗会带来风险.
- 早期TART诊断和监测的可靠方法对于保持男性生育能力至关重要.
研究的目的:
- 开发基于TART超声波特征的评分系统,以识别患有先天性上腺增生 (CAH) 的男性患者,患有不孕不育的高风险.
- 为了将超声波评估的丸损伤特征与CAH患者的精液参数相关联.
主要方法:
- 一项涉及灰度和功率多普勒超声波评估男性CAH患者丸病变的回顾性研究.
- 评估病变参数,包括大小,回声性和血管性.
- 病变得分与精液分析结果的相关性来自35名患者的49个样本.
主要成果:
- 在TART损伤得分和精子度 (rs = -0.83,P < 0.001) 和渐进性运动 (rs = -0.56,P < 0.001) 之间观察到显著的反相关性.
- 接收器操作特征 (ROC) 曲线分析显示,小精子症的面积为0.94,精子症的面积为0.72.
- 损伤得分值为6显示了75.00%的敏感性和93.94%的精子稀少性特异性,以及53.85%的敏感性和100.00%的精子稀少性特异性.
结论:
- 基于超声波的TART病变评分是评估男性CAH患者不孕症风险的宝贵工具.
- 将超声波纳入常规CAH管理中,可以促进及时进行干预,以保持男性生育能力.
- 这种评分系统有助于识别那些可能受益于更密切监测或调整治疗策略的患者.
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