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Updated: Jun 25, 2025

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

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埃布塞伦类似物通过对目标SOD-1的接触来延迟疾病的发病和其在fALS中的发展

Seiji Watanabe1, Kangsa Amporndanai2,3, Raheela Awais4

  • 1Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya, 464-8601, Japan.

Scientific reports
|May 27, 2024
PubMed
概括

研究人员发现,像MR6-26-2这样的ebselen类似物可以稳定SOD1二元体,这是肌缩侧面硬化症 (ALS) 的关键因素. 这种稳定提供神经保护,并改善SOD1相关的ALS小鼠模型的运动功能.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.药物开发 药物开发这就是Ebselen.运动神经元疾病 运动神经元疾病里卢醇是一种可靠的药物.超氧化物脱酶的作用目标参与度 目标参与度

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