人类腹中前额叶皮层对于亲社会动机是必要的
Patricia L Lockwood1,2,3,4, Jo Cutler5,6,7,8, Daniel Drew9,10,11
1Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK. P.L.Lockwood@bham.ac.uk.
Nature human behaviour
|May 27, 2024
概括
腹中前额叶皮层 (vmPFC) 的损伤会影响亲社会行为和决策. 特定的vmPFC子区域因果关系地影响了努力,奖励处理和社会选择.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 社会神经科学是一种社会神经科学.
背景情况:
- 腹中前额叶皮层 (vmPFC) 参与决策,奖励处理和亲社会行为.
- 以前的功能神经成像研究表明vmPFC参与,但其因果必然性仍然不清楚.
研究的目的:
- 研究腹中中前额叶皮质 (vmPFC) 在亲社会行为,基于努力的决策和奖励处理中的因果作用.
- 为了确定vmPFC的特定子区域是否在这些过程中具有不同的功能.
主要方法:
- 一项涉及焦点vmPFC病变患者 (n=25),其他病变患者 (n=15) 和健康对照组 (n=40) 的研究.
- 参与者完成了涉及休息和努力之间选择的任务,以为自己或他人赢得奖励.
- 基于Voxel的病变映射被用于将病变位置与行为结果相关联.
主要成果:
- vmPFC损害显著降低了亲社会性,减少了收入,并增加了基于努力的奖励折扣.
- 与对照组相比,患有vmPFC病变的患者在帮助他人时施加的力量较小.
- 基于voxel的损伤映射揭示了分离:中间vmPFC损伤导致反社会行为,而侧面损伤增加了亲社会性.
- vmPFC患者的整体劳动敏感性降低,奖励敏感性局部化到特定的子区域.
结论:
- 腹中前额叶皮层 (vmPFC) 在调节亲社会行为和基于努力的决策方面起着因果作用.
- 在vmPFC中,不同的子区域对亲社会性,奖励敏感性和努力估值有不同的贡献.
- 这些发现强调了vmPFC对于复杂的社会和经济选择的关键必要性.
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