用OCTA评估的血管密度模式的变化,用于糖尿病黄斑的患者,这些患者接受了抗VEGF治疗
Juan Santamaría1,2,3, Estefanía Cobos4, Marc Biarnes5,6
1Department of Ophthalmology, Hospital Universitari de Bellvitge, Carrer de La Feixa Llarga, S/N, 08907, L'Hospitalet de Llobregat, Catalunya, Spain. juanfra_s@hotmail.com.
Acta diabetologica
|May 27, 2024
概括
血管内皮生长因子抑制剂 (抗VEGF) 对糖尿病黄斑患者的血管密度的影响很小. 变化局部化到特定区域,与基线特征无关.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 视网膜疾病 视网膜疾病
背景情况:
- 糖尿病黄斑 (DME) 是导致视力丧失的主要原因.
- 抗血管内皮生长因子 (抗VEGF) 治疗是对DME的标准治疗方法.
- 了解治疗引起的视网膜血管结构的变化至关重要.
研究的目的:
- 在DME患者接受抗VEGF治疗后,评估血管密度 (VD) 的部门变化.
- 为了确定特定的视网膜层和受抗VEGF治疗影响的部门.
- 为了将静脉疾病的变化与基线临床特征相关联.
主要方法:
- 展望性干预研究涉及34名患有DME的患者 (48只眼睛).
- 使用了扫描源光学连贯断层扫描 (SS-OCT) 和部门OCT血管扫描 (OCTA).
- 在基线和抗VEGF治疗后6个月内测量了帕拉福韦尔静脉损伤.
主要成果:
- 总体上,静脉疾病的平均值显示,表面 (SCP) 和深层毛细血管 (DCP) 略有下降.
- 显著的VD减少 (2.9%) 仅在DCP的鼻腔部门观察到 (p=0.001).
- 鼻腔部门的基线VD是该地区VD变化的唯一预测因素.
结论:
- 抗VEGF疗法对DME患者的整体VD有很小的影响.
- 观察到的VD变异与血管异常和移位的血管有关,而不是缺血区域.
- 在VD变化与其他基线临床特征之间没有发现相关性.
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