kynurenine 途径在 COVID-19 神经病变发生过程中的作用
Mona Dehhaghi1, Mostafa Heydari2, Hamed Kazemi Shariat Panahi1
1Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
kynurenine 途径 (KP) 可能在 COVID-19 和长期 COVID 的神经效应中发挥重要作用. 感染期间炎症增加会激活导致神经毒性代谢物的酶,可能导致认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致COVID-19,与神经和心理疾病有关.
- 一些患者在急性感染期间经历"细胞因子风暴",干扰素和介质蛋白水平升高.
- 长期COVID,或COVID (PASC) 后急性后续,可能涉及持续的神经症状.
研究的目的:
- 为了探索 kynurenine 途径 (KP) 在 SARS-CoV-2 感染的神经病变发生过程中的潜在参与.
- 调查COVID-19中的炎症反应与KP激活之间的联系.
主要方法:
- 在急性COVID-19和PASC.中对细胞因子水平和KP代谢物度的现有数据的审查.
- 在SARS-CoV-2感染期间对酸盐代酶1 (IDO-1) 在酸盐代酶1 (IDO-1) 的作用的分析.
主要成果:
- 在急性COVID-19期间观察到高水平的促炎细胞因子 (IFN-γ,IFN-β,IL-6,TNF-α).
- 这些细胞因子激活IDO-1,通过KP启动托分解.
- 在急性COVID-19和PASC中发现了增加的KP代谢物,与认知障碍相关.
结论:
- kynurenine 途径很可能在 SARS-CoV-2 病变发生的神经学方面起着显著的作用.
- KP代谢物积累可能导致与急性COVID-19和长期COVID相关的神经系统疾病.
- 准KP可能是针对COVID-19相关的神经复发症的潜在治疗策略.
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