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炎症是否是相对握手力与高脂血症之间的缺失环节? 来自一项基于人口的大规模研究的证据

Rui La¹, Yunfei Yin², Wenquan Ding¹

¹Department of Orthopedic Surgery and Sports Medicine, The First Affiliated Hospital of Soochow University, Institute of Orthopedics at Soochow University, Jiangsu, China.

Lipids in health and disease

|May 27, 2024

概括

较高的相对握力 (RHGS) 与较低的超脂血症风险有关. 这可能是由于RHGS影响炎症过程,这表明它可能是一个保护因素.

科学领域:

心血管健康心血管健康
代谢健康代谢健康
炎症研究炎症研究

背景情况:

相对握力强度 (RHGS) 与心血管健康和代谢疾病风险相关.
在此之前,RHGS和高脂血症之间的关联是未知的.
假设炎症在RHGS-超脂血症关系中的潜在调解作用.

研究的目的:

调查RHGS和高脂血症之间的相关性.
检查炎症在这种关联中的调解作用.
使用国家健康和营养检查调查 (NHANES) 数据.

主要方法:

从NHANES (2011-2014) 分析了4610名参与者.
多变量逻辑回归模型来评估RHGS和超脂血相关性.
亚组分析,平滑曲线拟合,值效应分析和炎症标志物 (白细胞,中性粒细胞,淋巴细胞计数) 的调解分析.

主要成果:

在RHGS和高脂血症之间发现了显著的负相关性 (OR=0.575,95%CI=0.515-0.643).
这种关联在不同的人群中是一致的,特别是在女性中.
白细胞,中性粒细胞和淋巴细胞数量介导了这种关系,介导率分别为7.0%,4.3%和5.0%.

结论:

升高的RHGS是预防高脂血症的重要保护因素.
这些发现表明,RHGS可能通过调节炎症过程来减轻超脂血症风险.
RHGS可以被认为是高脂血症风险评估的潜在生物标志物.

关键词:

超脂血症是因为高脂血症炎症炎症是一种炎症.调解分析调解分析国家健康和营养检查调查调查相对握手的强度与握手的相对强度.

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