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肠道微生物群和焦虑障碍之间的关联:双向的双样本孟德尔随机化研究

Jianbing Li¹, Changhe Fan¹, Jiaqi Wang²

¹Department of Psychiatry, Guangdong Second Provincial General Hospital, Guangzhou, 510317, PR China.

|May 27, 2024

概括

这项研究使用了门德尔的随机化来探索肠道细菌和焦虑症 (AD) 之间的因果关系. 发现某些肠道细菌属与AD风险增加或降低有因果关系.

科学领域:

微生物组研究的研究.
神经科学是一个神经科学.
遗传学遗传学是一个

背景情况:

越来越多的证据表明肠道微生物群与焦虑症 (AD) 之间存在联系.
大脑-肠轴是研究的一个关键领域,但肠道微生物群和AD之间的确切关系仍然不清楚.
双向门德尔随机化 (MR) 用于调查潜在的因果关系.

研究的目的:

调查肠道微生物群组成和焦虑症 (AD) 之间的因果关系.
为了确定与发展AD的风险相关的特定细菌属.

主要方法:

利用来自肠道微生物群的大型全基因组关联研究 (GWAS) (18,340名参与者) 的遗传仪器变量.
使用来自GWAS的AD总结数据 (158,565例,300,995例对照).
应用了逆方差加权 (IVW) 方法,并进行了灵敏度分析 (Cochran's Q,MR-Egger,MR-PRESSO) 以确保稳定性和测试变性.

主要成果:

确定了9种细菌属和AD风险之间的潜在因果关系.
五个细菌系 (Eubacteriumbrachygroup,Coprococcus3,Enterorhabdus,Oxalobacter,Ruminiclostridium6) 显示与AD风险存在积极的相关性.
四个细菌系 (Blautia,Butyricicoccus,Erysipelotrichaceae-UCG003,Parasutterella) 表明与AD风险的负相关性,通过敏感性分析证实了这一点.

结论:

确定了特定的肠道微生物群组成部分和焦虑症 (AD) 之间的因果关系.
这些发现凸显了肠道微生物组在AD病因学中的潜在作用.
建议进行进一步的研究,包括对益生菌的随机对照试验,以了解对AD的保护机制.

关键词:

焦虑症焦虑症焦虑症我们的肠道微生物群.门德尔的随机化单个核酸的多态性.

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