参与瑞士乳腺癌查计划"donna"的乳腺癌患者表现出长时间的存活率
David Kuklinski1, Marcel Blum2, Jonas Subelack3
1Chair of Health Economics, Policy and Management, School of Medicine, University of St. Gallen, St. Jakobstr. 21, 9000, St. Gallen, Switzerland. David.kuklinski@unisg.ch.
Breast cancer research : BCR
|May 27, 2024
概括
参与"donna"乳房扫描查计划 (MSP) 的女性,乳腺癌 (BC) 存活率显著提高. 通过MSP进行早期检测可以改善结果,尽管早期诊断阶段仅部分解释了生存益处.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 医疗成像医学成像
背景情况:
- 乳腺扫描查计划 (MSP) 旨在早期检测乳腺癌 (BC).
- 评估MSP对患者存活率的影响对于计划评估至关重要.
研究的目的:
- 为了比较乳腺癌 (BC) 妇女的存活率检测在"女"乳房扫描查计划 (MSP) 与检测在该计划之外.
主要方法:
- 来自MSP和癌症登记册的数据被合并,以对BC病例进行分类.
- 分析了瘤的阶段,特征和生存率.
- 考克斯回归和领先时间偏差校正用于估计生存差异.
主要成果:
- 在MSP中检测到的BC显示了更高比例的I期癌症 (46.5%与33.0%) 和较小的瘤大小 (19.1毫米与24.9毫米).
- 在MSP的女性中,10年生存率明显高 (91.4%),而在MSP以外的女性中则高 (72.1%).
- 领先时间纠正的危险比率表明MSP参与者的总生存率 (0.550) 和BC特定生存率 (0.469) 得到改善.
结论:
- 参与"donna"MSP与明显更高的整体和与乳腺癌相关的生存率有关.
- 在较不晚的阶段早期发现BC有助于改善存活率,但并不能完全解释观察到的差异.
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