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[使用白血病治疗方案治疗儿童T-淋巴细胞淋巴瘤的预后分析]

Shu-Min Hou¹, Jing-Bo Shao¹, Hong Li¹

¹Department of Hematology/Oncology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200040, China.

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

|May 27, 2024

概括

儿童T-淋巴细胞淋巴瘤 (T-LBL) 与急性淋巴细胞白血病 (ALL) 方案的预后良好,总生存率达到84%. 然而,B系统性症状,高血小板计数和中/淋巴结干扰表明T-LBL患者的结果较差.

科学领域:

儿科瘤学儿科瘤学
血液学血液学血液学
淋巴瘤研究淋巴瘤研究

背景情况:

儿童T-淋巴细胞淋巴瘤 (T-LBL) 是一种非霍奇金淋巴瘤的攻击性亚型.
治疗通常涉及针对急性淋巴细胞白血病 (ALL) 设计的治疗方案.
了解预后因素对于优化T-LBL管理至关重要.

研究的目的:

为了评估儿童T-淋巴细胞淋巴瘤 (T-LBL) 的预后,治疗急性淋巴细胞白血病 (ALL) 化疗方案.
确定影响小儿T-LBL患者生存结果的因素.

主要方法:

在2010年5月至2022年5月期间,对29名儿科T-LBL患者进行了回顾性分析,这些患者接受了ALL-2009或CCCG-ALL-2015治疗方案.
预后特征的评估,包括临床症状,实验室发现和治疗方案.

主要成果:

五年总生存率 (OS) 和无事件生存率 (EFS) 分别为84%±7%和81%±8%.
与更差的预后相关的因素包括B系统症状,血小板数>400×10^9/L,以及中和淋巴结的参与.
与ALL-2009疗法相比,CCCG-ALL-2015疗法降低了高剂量甲状腺素的频率和严重感染,但没有影响生存率.

结论:

急性淋巴细胞白血病 (ALL) 方案在治疗儿童T-淋巴细胞淋巴瘤 (T-LBL) 中是有效和安全的.
识别患有B系统症状,血小板数升高或中和淋巴结参与的患者是预测不良预后的关键.
修改化疗方案,例如减少高剂量甲状腺素,可以降低感染率,而不会影响患者的治疗结果.

关键词:

孩子孩子孩子孩子孩子孩子预测预后预测预测在T-淋巴细胞淋巴瘤.治疗方法治疗方法

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