[有正常肺透气功能的支气管喘儿童急性发作的控制状况和随访]
Lan-Lan Ma1, Ling Chen1, Qin Wang1
1Department of Pediatric Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
概括
在有正常肺功能的三分之一的学龄儿童中,喘控制仍然不完全. 具有较低FEV1/FVC比率的儿童面临更高的急性喘发作风险.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 临床儿科 临床儿科
背景情况:
- 喘是儿童常见的慢性呼吸道疾病.
- 通常认为正常的肺通风功能表明了良好的喘控制.
- 然而,控制状态和正常肺功能儿童急性恶化风险需要进一步调查.
研究的目的:
- 评估正常肺透气功能的学龄儿童的喘控制状态.
- 为了评估急性喘发作发生率在一年的随访期内.
- 识别与喘控制不良和急性喘发作相关的潜在风险因素.
主要方法:
- 对327名患有喘且肺呼吸正常的儿童 (6-14岁) 的临床数据的回顾性分析.
- 儿童根据他们每秒强制呼吸量与强制生命能力比率 (FEV1/FVC) 进行分类:≥80% (n=267) 和<80% (n=60).
- 肺呼吸功能,喘控制水平和两组人群在一年内发生急性喘发作的比较.
主要成果:
- 与≥80%组 (P<0.05) 相比,FEV1/FVC<80%的组表现出较低的基线肺功能和较高的小气道功能障碍患病率.
- 尽管治疗后有所改善,但小气道功能在<80%组中仍然较低. 基线不完全控制喘在所有儿童的34.6%中观察到,<80%的组显示控制较差 (P<0.05).
- 一年后,<80%的组继续有较低的喘控制水平和明显更高的急性喘发作比例 (P<0.05).
结论:
- 大约三分之一的学龄儿童患有喘,即使有正常的肺呼吸功能,也无法完全控制喘.
- 患FEV1/FVC <80%的儿童患急性喘发作的风险增加.
- 这些发现强调了需要密切监测和加强喘管理策略在这个小儿科患者的小组.
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