微生物免疫球蛋白涂层,阴道微生物群,种族和早产之间的相互关系
H J Schuster1,2,3,4, A C Breedveld5,6, S P F Matamoros7,5
1Amsterdam UMC location Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Boelelaan 1117, Amsterdam, The Netherlands. h.schuster@amsterdamumc.nl.
Microbiome
|May 27, 2024
概括
阴道微生物群的组成显著影响了自发早产 (sPTB) 的风险,而种族也起到了作用. 涉及阴道免疫球蛋白 (Igs) 的宿主微生物相互作用可能会影响这种关系.
科学领域:
- 生殖免疫学 生殖免疫学
- 微生物组研究的研究.
- 围产期健康 围产期健康
背景情况:
- 阴道微生物群的组成与自发早产 (sPTB) 有关,跨种族观察到的差异.
- 宿主微生物群相互作用被假设为调解种族,阴道微生物群和sPTB之间的关系.
研究的目的:
- 为了研究阴道微生物组成,阴道免疫球蛋白 (Igs) 和无卵性孕妇的炎症标志物之间的关联.
- 在种族和sPTB的背景下探索宿主微生物相互作用的作用.
主要方法:
- 预期性对象群研究,对无胎孕孕妇进行研究.
- 评估阴道微生物组成,阴道免疫球蛋白 (Igs) 和局部炎症标志物.
- 嵌套病例控制研究比较了19个sPTB病例与19个匹配的术语控制.
主要成果:
- 乳杆菌内在者占主导地位的微生物群,多样化的微生物群和种族独立地与sPTB相关.
- 微生物Ig涂层与微生物群组成和种族相关,但与sPTB没有直接关联.
- 在各种微生物群中观察到较低的微生物IgA和IgG涂层,特别是在少数民族妇女中,在控制微生物群时,与较高的Ig涂层相关的炎症增加.
结论:
- 阴道微生物群的组成是sPTB的强有力的预测器.
- 阴道粘膜Igs可能调节微生物群组成,炎症和跨种族社区差异.
- 研究结果表明,阴道粘膜Igs在宿主微生物相互作用中的潜在免疫调节作用类似于肠道.
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