对初潮时的年龄和自然更年期的年龄进行全代谢门德尔随机化
Mojgan Yazdanpanah1, Nahid Yazdanpanah1, Isabel Gamache1
1Research Center of the Sainte-Justine University Hospital, Université de Montréal, 3175 Côte-Sainte-Catherine, Montréal, Québec, H3T 1C5, Canada.
Genome medicine
|May 27, 2024
概括
代谢物,特别是来自甘氨酸和脂肪酸家族的代谢物,影响女性生殖里程碑的时间,如初潮和更年期,影响生殖寿命.
科学领域:
- 生殖生物学 生殖生物学
- 代谢学 代谢学 代谢学
- 遗传流行病学遗传流行病学
背景情况:
- 代谢对初潮时的年龄 (AAM) 和自然更年期 (ANM) 的年龄的影响尚未完全理解.
- 研究循环代谢物和生殖时间之间的因果关系对于了解女性生殖寿命至关重要.
研究的目的:
- 研究循环代谢物的因果作用,以确定初潮年龄 (AAM) 和自然更年期 (ANM) 的年龄.
- 为了确定与女性生殖时间相关的特定代谢途径和代谢物.
主要方法:
- 采用孟德尔随机化 (MR) 结合遗传局部化来评估数百种代谢物和AAM/ANM之间的因果关系.
- 利用了来自ReproGen联盟的大型全基因组关联研究 (GWAS) 的数据,并验证了Avon长度研究父母和儿童 (ALSPAC) 中的发现.
- 评估了身体质量指数 (BMI) 的调解作用,并确定了相关的代谢途径.
主要成果:
- 在同位化分析后,没有发现AAM的显著因果代谢物.
- 鉴定出17种ANM的同色化代谢物,主要来自甘油,欧米茄-3脂肪酸和酸丁 (PC) 类.
- 途径分析和ALSPAC验证证实了欧米茄和多不和脂肪酸在延迟更年期中的作用.
结论:
- 甘氨酸和脂肪酸家族中的代谢物因果关系地影响女性生殖事件的时间.
- 特定的代谢途径对女性生殖寿命的生物调节具有重要意义.
更多相关视频
06:38Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
15.4K
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.2K
相关概念视频
01:28Menopause
155
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
155
02:07Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K