通过双尾表面活性剂控制离子复合囊泡的形成
1Shiseido Co., Ltd., MIRAI Technology Institute, Yokohama, Japan.
International journal of cosmetic science
|May 28, 2024
概括
由阴离子和阴离子表面活性剂形成的离子复合囊泡提供了化品乳液中脂质体的稳定,高质感的替代品. 这些新型囊泡提供了极好的皮肤粘附性,并且在各种温度下保持稳定.
科学领域:
- 材料科学:开发用于化品应用的新型囊泡输送系统.
- 合体和表面化学:研究表面活性剂之间的离子复合体形成.
背景情况:
- 脂质体广泛用于化品,但容易发生氧化降解和稳定性问题.
- 化脂提高了稳定性,但由于高相位过渡温度而存在挑战.
- 阴离子表面活性剂通常形成囊泡,但在特定的乳液类型之外,在护肤领域的应用有限.
研究的目的:
- 通过克服传统脂质体的局限性,开发稳定,高性能囊泡用于化品应用.
- 用双尾阴离子和阴离子表面活性剂作为脂质体的替代品创建离子复合囊泡.
主要方法:
- 使用二甲基二甲基氨基化物 (DSAC) 和二甲基氨基胺酸 (DLGL) 合成和描述离子复合囊泡.
- 使用差分扫描热量计 (DSC) 和X射线散射 (SWAXS) 确定相位图.
- 囊泡形态通过低温传输电子显微镜 (cryo-TEM) 证实.
- 在体内皮肤吸附被用极化红外外反射 (PIR-ER) 评估.
- 化品乳液配方和稳定性测试,用动态光散射 (DLS) 分析囊泡大小.
主要成果:
- 稳定的多叶膜囊泡 (直径<100纳米) 在DLGL:DSAC摩尔比为6:4时形成.
- 化TEM证实了囊泡的形成,而PIR-ER证明了皮肤上的垂直方向.
- 制造了一种含有63.2nm囊泡的稳定化品乳液,在不同温度 (0-50°C) 中表现出一个多月的稳定性.
结论:
- 离子复合囊泡很容易通过凝固过程产生.
- 观察到的皮肤吸附结构表明其优良的纹理特性与基于脂质体的乳液相似.
- 这些新的离子复合体囊泡代表了化品配方中传统脂质体的可行替代品.
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