治疗下泌尿道症状的α-上腺抗剂的使用与认知功能恶化无关
Fernanda Gabrigna Berto1, J Andrew McClure2, Jeffrey Campbell1
1Department of Surgery, Western University, London, Ontario, Canada.
Neurourology and urodynamics
|May 28, 2024
概括
用于LUTS的α-上腺抗剂不会增加认知能力下降的风险. 这项研究发现,这些药物的新用户和非用户之间的认知衰退没有显著差异.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 阿尔法上腺抗剂通常用于下泌尿道症状 (LUTS).
- 人们担心阿尔法上腺抗剂使用与痴呆症之间存在潜在的关联.
- 这项研究旨在调查这些药物的新用户认知能力下降的风险.
研究的目的:
- 为了确定是否新的阿尔法上腺抗剂使用者面临认知能力下降的风险增加.
- 为了比较阿尔法上腺抗剂使用者和非使用者之间的认知衰退率.
- 评估这些药物对不同认知状态的个体认知功能的影响.
主要方法:
- 使用国家阿尔茨海默氏症协调中心 (NACC) 数据集的回顾性队列研究.
- 根据倾向分数,与916名非使用者匹配了916名阿尔法上腺抗剂的新用户.
- 主要结局:通过临床痴呆评分 (CDR) 或迷你精神状态检查 (MMSE) 测量临床相关的认知衰退.
主要成果:
- 暴露和非暴露组之间的基线特征没有显著差异.
- 用户和非用户之间的认知分数 (CDR,MMSE) 没有统计学上显著的差异.
- 认知能力下降发生在9.72%的使用者和8.19%的非使用者 (CDR) 中,没有发现显著的关联 (OR1.34,p=0.14).
结论:
- 对LUTS的α-上腺抗剂似乎不会增加认知能力下降的风险.
- 这些发现为临床医生和患者提供了关于这些药物的认知安全性的保证.
- 在认知状态或APOE基因型的分层分析中没有发现显著的关联.
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