加速大脑衰老对帕金森病中同活化模式动态的影响
Su Yan1, Jun Lu2, Hongquan Zhu1
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of neuroscience research
|May 28, 2024
概括
帕金森病患者表现出加速的大脑衰老,影响大脑网络动态. 这表明,针对大脑衰老的干预措施可以改变疾病的进展.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 衰老研究研究 衰老研究
背景情况:
- 衰老是神经退行的主要危险因素,帕金森病 (PD) 呈现加速衰老模式.
- 了解PD中结构性大脑衰老和功能网络动态之间的联系对于神经退行性疾病研究至关重要.
研究的目的:
- 调查结构性大脑衰老如何影响帕金森病患者大规模功能性大脑网络的时间动态.
- 探索大脑年龄差距估计和PD中的功能网络改变之间的关系.
主要方法:
- 从62名PD患者和32名健康对照 (HC) 的结构性MRI中计算出全球和本地大脑年龄差距估计 (G-brainAGE和L-brainAGE).
- 使用休息状态fMRI的同活化模式 (CAPs) 捕获全脑神经活动.
- 使用一般线性模型评估跨组差异,并执行L-brainAGE和CAPs之间的空间相关性.
主要成果:
- 与HC相比,PD患者的G-大脑AGE显著增加 (+1.93年) 和L-大脑AGE普遍升高 (-3.73年).
- G-brainAGE与PD严重程度和持续时间相关.
- 患有PD的患者在默认模式-前对等 (DMN-FPN) 和感觉运动- Salience (SMN-SN) 网络 CAP 中的时间缩短,并且向这些 CAP 过渡的时间减少.
- 局部化大脑年龄加速与SMN-SN CAP空间相关.
结论:
- 在PD中加速的结构性大脑衰老会对大脑功能产生不利影响,导致大脑网络动态失调.
- 研究结果提供了对神经退行机制的见解,并建议通过针对大脑衰老来减缓PD进展的潜在干预措施.
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