在减肥期间,胰岛素敏感性和瘦肉量损失之间的关联
Ciera L Bartholomew1, Catia Martins1, Barbara Gower1
1Department of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.
Obesity (Silver Spring, Md.)
|May 28, 2024
概括
较低的胰岛素敏感性预测在减肥干预期间,较大瘦身量损失. 识别胰岛素敏感性较低的个体可能使个性化策略能够最大限度地减少肌肉损失.
科学领域:
- 代谢和内分泌学
- 人体生理学 人体生理学
- 营养科学 营养科学
背景情况:
- 胰岛素敏感性在代谢调节中起着至关重要的作用.
- 了解影响减肥期间身体组成变化的因素对健康至关重要.
- 保持瘦身量对新陈代谢健康和功能很重要.
研究的目的:
- 为了研究在16周的减肥干预期间,基线胰岛素敏感性和总瘦质量 (LM) 和尾LM (ALM) 的变化之间的关系.
- 为了确定胰岛素敏感性是否预测了饮食诱导的减肥期间失去的瘦肉量.
主要方法:
- 这是一项随机对照试验,涉及57名肥胖参与者 (BMI 32.1 ± 3.8 kg/m2).
- 参与者遵循标准或适度减少碳水化合物的饮食16周.
- 使用双能X射线吸收计评估身体组成,通过静脉输入葡萄糖耐受性测试测量胰岛素敏感度指数 (SI).
主要成果:
- 参与者平均减轻了6.8公斤,总LM (1.5公斤) 和ALM (0.5公斤) 的损失显著.
- 基线胰岛素敏感性 (SI) 与调整共变量后的总LM (β = 0.481,p < 0.001) 和ALM (β = 0.359,p < 0.05) 的变化相反相关.
- 即使考虑到基线LM,脂肪质量和对葡萄糖的急性胰岛素反应,这些关联仍然显著.
结论:
- 在基线时胰岛素敏感性较低的个体在减肥期间倾向于失去更多的肌肉质量.
- 在减肥干预措施之前,识别胰岛素敏感性较低的个体可能会促进个性化的方法.
- 有针对性的策略可能有助于最大限度地减少体重减轻的易受影响的个体的瘦身量损失.
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