ангиопоетин2 与 COVID-19 中细胞外囊泡中的凝血激活和组织因子表达有关
Mayck Silva Barbosa1, Franciele de Lima1, Carla Roberta Peachazepi Moraes1
1School of Medical Sciences, Universidade Estadual de Campinas, Campinas, Brazil.
Frontiers in medicine
|May 28, 2024
概括
血管新生素/Tie2通路与COVID-19凝血病有关. 受ANGPT2影响的携带组织因子的细胞外囊泡增加,有助于这一过程.
科学领域:
- 免疫血栓形成的疾病.
- 血管生物学 血管生物学
- 凝血障碍 凝血障碍 凝血障碍
背景情况:
- 免疫血栓形成涉及独特的凝血途径,与静血不同,呈现治疗点.
- ангиопоетин/Tie2通路调节内皮壁垒,并已涉及败血症和COVID-19相关的凝血.
- 了解 ангиопоэтин/Tie2通路在COVID-19凝血病中的作用对于向治疗至关重要.
研究的目的:
- 为了研究angiopoietin/Tie2通路调解者与COVID-19患者的凝血激活之间的关联.
- 确定细胞外囊泡 (EVs) 在调解这种途径对凝血的影响中的作用.
- 探索特定途径组件与组织因子 (TF) 活性之间的关系.
主要方法:
- 来自COVID-19患者缺氧和健康对照者的血分析.
- 使用流式细胞计量对EV进行量化和表征.
- 测量组织因子 (TF) 凝血活性,评估血液静止标志物.
主要成果:
- 增加的 ангиопоэтин-1 (ANGPT1), ангиопоэтин-2 (ANGPT2) 和可溶性Tie2的水平与凝血和血小板激活标志物相关.
- 在COVID-19患者中观察到血小板和内皮细胞衍生的EV的增加.
- 从内皮细胞表达TF的EV显著增加,与TF表达和活性相关的ANGPT2水平.
结论:
- 血管新生素/Tie2通路有助于COVID-19凝血病.
- 在这个过程中,EVs,特别是那些来自内皮细胞并表达TF的EVs,起着作用.
- ANGPT2参与调节EV上的TF活性,这表明它是一个潜在的治疗点.
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
7.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.2K
01:10Mechanism of Angiogenesis
5.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.4K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
681
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
681
01:24Overview of Cell-Matrix Interactions
7.2K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.2K