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托法西提尼布用于治疗耐火性免疫检查点抑制剂相关的免疫炎
Kiran Shivaraj1, Amanda Tchakarov2, Yanlan Dong1
1Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Clinical kidney journal
|May 28, 2024
概括
免疫检查点抑制剂 (ICI) 相关性炎可能对标准治疗不耐药. 托法西提尼布是一种简氏激酶 (JAK) 抑制剂,在患有耐火性免疫炎的患者中成功降低了类固醇依赖.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 免疫检查点抑制剂 (ICI) 可以导致免疫炎,这是一个罕见但严重的副作用.
- 目前的指导方针建议在ICI相关的急性间歇性炎 (AIN) 时使用类固醇和infliximab.
- 一些AIN病例对标准治疗具有耐药性,这表明需要使用替代疗法.
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