运动是否会改变老年人的阿尔茨海默病病理生理学?
J Raffin1,2
1Institut Hospitalo-Universitaire (IHU) HealthAge, Toulouse, France.
JAR life
|May 28, 2024
概括
身体炼对阿尔茨海默病生物标志物的影响有限. 然而,特定群体,如代谢问题和APOE-ε4载体的妇女,可能会获得好处.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 运动生理学 运动生理学
背景情况:
- 身体炼因其对大脑健康的积极影响而得到认可.
- 关联运动与认知效益的确切机制,特别是在阿尔茨海默病 (AD) 中,需要进一步阐明.
- 诸如β-粉样蛋白,陶蛋白,神经纤维光链和状纤维酸性蛋白质等生物标志物对于理解AD病理生理学至关重要.
研究的目的:
- 审查调查运动训练对AD生物标志物影响的干预研究.
- 评估运动对中老年和老年人特异性和非特异性AD生物标志物的影响.
主要方法:
- 对受控运动干预研究的系统审查.
- 包括标准:英语,至少2周的干预,中年/老年人,测定β-粉样蛋白,tau,神经丝光链或状纤维酸性蛋白质.
- 在大脑,脑脊液或血液中测量的生物标志物.
主要成果:
- 没有强有力的证据表明运动干预对一般人群中选定的AD生物标志物的显著影响.
- 在特定人群中观察到血液β-粉样蛋白度的有利变化,包括患有肥胖,糖尿病前期或抑郁症的女性.
- 在携带APOE-ε4等位基的阿尔茨海默病患者中,对脑脊液β-粉样蛋白的积极影响被注意到.
结论:
- 目前的证据表明,在更广泛的中年和老年成人群体中,体育炼不会显著改变阿尔茨海默病的病理生理学.
- 某些子组,如代谢障碍的妇女和APOE-ε4阳性AD患者,可能会经历AD生物标志物的有益调节.
- 需要进行进一步的研究,进行长时间的随访,更大的样本大小,并考虑静坐行为和饮食等混因素.
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