术内胆培养结果与随后的术后感染性并发症之间的关系:一项回顾性队列研究
Jaime Alberto Ramírez-Arbeláez1, Ricardo Leonel Arroyave-Zuluaga2, Luis Manuel Barrera-Lozano1,2
1Department of Transplants, Hospital San Vicente Fundación, Rionegro, Colombia.
BioMed research international
|May 28, 2024
概括
阳性手术内胆培养物 (bactobilia) 显著增加了肝胆瘤手术患者手术后感染的风险. 快速胆汁培养分析对于管理这些传染性并发症至关重要.
科学领域:
- 肝胆道手术 肝胆道手术
- 传染病流行病学 传染病流行病学
- 微生物学 微生物学
背景情况:
- 术内阳性胆汁培养 (bactobilia) 与肝胆瘤手术中更差的结果有关.
- 细菌菌对术后并发症的确切影响需要进一步澄清,因为文献不一致.
- 这项研究调查了手术内胆汁培养结果与术后感染性并发症之间的关联.
研究的目的:
- 确定术后胆汁培养状态与术后感染并发症发生率之间的关系.
- 识别与细菌生物有关的特定微生物及其流行情况.
- 评估阳性胆培养作为感染发展的独立预测因素.
主要方法:
- 对137名接受重大肝胆胰腺手术的患者进行了回顾性队列研究.
- 对微生物生长进行手术内胆汁培养的分析.
- 在有和没有bactobilia的患者之间比较术后感染性并发症的发生率.
- 后勤回归分析以确定感染的独立风险因素.
主要成果:
- 与负培养 (11.1%) (p = 0.002) 相比,带有细菌菌的患者感染并发症的发生率明显高 (35.1%).
- 在细菌培养组 (24.3%) 与负培养组 (7.9%) (p = 0.01) 中,手术部位感染的发生频率更高.
- 格拉姆阴性细菌,主要是肠杆菌 (例如,大肠杆菌,肺炎菌),主导的正培养. 阳性胆汁培养是感染的独立预测因子 (OR:2.26;p = 0.02).
结论:
- 在手术期间的细菌体是肝瘤手术后术后传染性并发症的重要危险因素.
- 常规的手术内胆汁培养对于识别有风险的患者和指导管理至关重要.
- 及时识别和管理细菌生物可能有助于缓解术后感染性并发症.
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