相关实验视频

Updated: Jun 25, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

免疫-瘤相互作用决定食道状细胞癌的空间定向进化

Yong Zhou^1,2,3, Shanlan Mo⁴, Heyang Cui^1,2,5

¹Cancer Institute, Department of Pathology, Peking University Shenzhen Hospital, Shenzhen Peking University-the Hong Kong University of Science and Technology (PKU-HKUST) Medical Center; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518000, China.

National science review

|May 28, 2024

概括

食道状细胞癌 (ESCC) 在空间上演变,子克隆向上扩张并经历免疫选择. 针对这种异质性是有效精密治疗的关键.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
癌症生物学癌症生物学

背景情况:

食道状细胞癌 (ESCC) 呈现出显著的基因组和瘤微环境 (TME) 异质性.
了解ESCC的空间异质性模式和驱动因素至关重要,但在很大程度上是未知的.

研究的目的:

研究ESCC的空间基因组和微环境异质性.
确定空间演变的驱动因素及其对临床结果和治疗目标的影响.

主要方法:

从103名ESCC患者的整体外体,转录组和甲基组测序中生成了一个空间多原子地图.
分析了TME,量化了亚克隆扩张,并评估了免疫编辑和免疫选择.

主要成果:

在22%的ESCC中确定PREX2作为一种新的瘤抑制剂,促进细胞迁移和入侵.
ESCCs表现出空间定向的进化,偏向向食道上部的克隆扩张.
在上层ESCC区域观察到更强的免疫编辑和免疫选择.
不同的TME与基因组和临床结果相关;热的TME与免疫逃避和亚克隆异质性有关.
免疫编辑,而不是CD8+T细胞丰度,是一个独立的预后因素.
治疗目标和BRCAness特征的显著异质性.

结论:

空间进化和免疫编辑是ESCC的关键机制.
在TME和基因组学中的异质性会影响预后和治疗策略.
对于ESCC的精密治疗必须解决患者内异质性.

关键词:

进化演化演化演化演化演化演化不同质性的异质性多种主题的多种主题.状细胞癌的癌症.瘤微环境是一个微环境.

更多相关视频

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.