食纤维可能有利于维持状细胞活动
Ying Wu1,2,3, XiangJie Li1,3, Hao Meng1
1Department of Orthopedics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Frontiers in cellular and infection microbiology
|May 28, 2024
概括
高食纤维摄入量促进有益的肠道细菌,上调Sestrin2 (SESN2) 表达,并通过改善肠道屏障功能和降低炎症来减少骨关节炎的进展.
科学领域:
- 微生物学 微生物学
- 整形外科 整形外科 整形外科
- 胃肠病学 胃肠病学
背景情况:
- 肠-骨轴将肠道健康与骨完整性联系在一起,但潜在的机制尚不清楚.
- 骨关节炎 (OA) 涉及关节炎症和软骨退化,受到系统因素的影响.
研究的目的:
- 研究Sestrin2 (SESN2) 途径在肠骨轴中的作用.
- 在大鼠模型中确定高食纤维 (HDF) 对肠道微生物群和OA发展的影响.
主要方法:
- 前交叉带切断 (ACLT) 在斯普拉格-道利大鼠中诱导了OA.
- 饮食干预,在8周内改变纤维含量.
- 进行了16S rRNA测序,ELISA和组织学分析.
主要成果:
- HDF显著增加了巴西洛塔主导的肠道微生物群.
- HDF干预减少了骨和关节病变和炎症.
- HDF在膝关节上升调节的SESN2表达.
结论:
- HDF的摄入调节了肠道微生物群,可能会增加细菌群.
- 高强度脂肪酸可能通过上调膝关节SESN2表达,降低肠道透性和降低全身炎症来延迟关节炎的发生.
- 这突出了影响肠骨轴和管理OA的饮食策略.
相关概念视频
Growth of Cartilage and Bone Tissue
3.2K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.2K
Collagens are the Major Structural Proteins of ECM
4.1K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
4.1K
Extracellular Matrix
2.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
2.9K
Matrix Proteoglycans and Glycoproteins
3.9K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
3.9K
Elastin is Responsible for Tissue Elasticity
2.3K
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
2.3K
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K


