2型糖尿病患者的非冠状动脉外周动脉并发症:瑞典回顾性队列研究
Araz Rawshani1,2,3, Björn Eliasson3, Jan Boren1,2
1Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sweden.
The Lancet regional health. Europe
|May 28, 2024
概括
2型糖尿病的外周动脉并发症显著减少,除了大动脉动脉瘤. 控制血红蛋白A1c,血压和吸烟是降低风险的关键.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 与一般人群相比,对2型糖尿病中外周动脉并发症的长期趋势和风险因素的研究有限.
- 这项研究调查了糖尿病患者与对照患者的最佳风险因素,其意义和多因素风险控制.
研究的目的:
- 确定2型糖尿病中外围动脉并发症的趋势和危险因素.
- 将这些趋势和风险与一般人群进行比较.
- 评估多因素风险因素控制的影响.
主要方法:
- 利用瑞典国家糖尿病登记 (2001-2019) 的数据,包括655,250名2型糖尿病患者和匹配的对照.
- 分析了发病率并使用考克斯回归来评估结果:脑外大动脉疾病,大动脉动脉瘤,大动脉剖析,下肢动脉疾病和糖尿病足病.
- 确定了基线血红蛋白A1c (HbA1c),缩血压 (SBP),吸烟和脂质水平与结果之间的关联.
主要成果:
- 大多数非冠状动脉外围动脉并发症的发病率在2001-2019年期间下降,除了大动脉动脉瘤.
- 较高的HbA1c,SBP和吸烟与所有结果独立相关.
- 与对照人群相比,患有2型糖尿病的人患额外大动脉疾病 (HR 1.69) 和下肢动脉疾病 (HR 2.59) 的风险更高.
结论:
- 在2型糖尿病中观察到的非冠状动脉外周动脉并发症的显著下降,除了大动脉动脉瘤.
- HbA1c,吸烟和血压是这些并发症的主要原因.
- 降低心脏代谢风险因素与这些不良结果的风险降低有关.
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