标准的动物饮食对酒精消费,偏好和肠道微生物群多样性有不同的影响
Aline Zaparte1, Evan Dore2, Selby White2
1Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, United States.
Frontiers in neuroscience
|May 28, 2024
概括
动物的饮食成分显著影响小鼠的酒精消费和饮酒偏好. 改变饮食迅速改变酒精摄入量,这表明饮食,肠道微生物组和酒精使用障碍行为之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 酒精使用障碍 (AUD) 是一种普遍的疾病,治疗选择很少.
- 临床前模型对于研究AUD至关重要,但酒精消费的变化阻碍了可重现性.
- 动物的饮食成分越来越被认为是影响酒精摄入量的因素.
研究的目的:
- 调查三种商用动物饮食对C57BL/6J小鼠酒精消费和饮酒偏好的影响.
- 为了确定饮食变化是否能快速改变酒精摄入量和偏好.
- 探索饮食,味觉感知,强迫行为和肠道微生物组在饮酒背景下的关系.
主要方法:
- 在小鼠的酒精消耗中使用了24小时间歇性访问程序.
- 在三种不同的动物饮食配方 (LabDiet 5001,LabDiet 5053,Teklad 2019S) 中比较了酒精摄入量和偏好.
- 评估了糖,糖和因的偏好,以评估味觉. 在接受不同饮食的小鼠中分析了肠道微生物组合 (α和β多样性).
主要成果:
- 吃LabDiet 5001和LabDiet 5053的小鼠的酒精消耗和偏好明显高于吃Teklad 2019S.的小鼠.
- 在服用酒精前48小时的饮食改变迅速改变了饮酒消费和偏好.
- 没有观察到糖,糖或因偏好的显著变化,这表明饮食不会影响基本的味觉感知.
- 实验室饮食5001的消费与增加的抗素酒精摄入量有关,这表明对强迫行为有潜在的影响.
- 在不同饮食的小鼠之间发现了肠道微生物群多样性的显著差异,可能会影响肠-大脑轴.
结论:
- 动物的饮食组成是影响酒精消费和偏好的关键变量,在临床前AUD模型中.
- 饮食干预为研究环境中调节酒精摄入量提供了一个潜在的策略.
- 由饮食驱动的肠道微生物组变化可能在强迫性饮酒行为发展中发挥作用.
- 未来的研究应该考虑饮食标准化,并在AUD研究中探索肠-大脑轴.
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