解码巴雷特食道和食道腺癌之间的常见遗传变化:生物信息学分析
Pooya Jalali1, Alireza Yaghoobi1, Malihe Rezaee1
1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Heliyon
|May 28, 2024
概括
这项研究确定了关键的基因和分子途径,将巴雷特食道 (BE) 与食道腺癌 (EAC) 联系起来. 这些发现可能会导致新的诊断工具和治疗目标,以防止EAC的进展.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 生物信息学是一种生物信息学.
背景情况:
- 食道腺癌 (EAC) 是一个重要的健康问题,在晚期预后不佳.
- 巴雷特食道 (BE) 是已知的EAC前体,强调了早期检测和干预的必要性.
- 确定BE-EAC进展中的分子驱动因素对于开发有效的治疗方法至关重要.
研究的目的:
- 为了确定从BE到EAC的进展中涉及的基本调节基因和分子贡献者.
- 检测不同表达的基因 (DEGs) 和单核酸多态 (SNPs) 是BE和EAC共同的.
- 构建基因调节网络并确定潜在的治疗点.
主要方法:
- 微阵列数据集的全面生物信息学分析.
- 使用了 DEG 和 SNP 的 GEO 和 DisGeNET 数据库.
- 构建的蛋白质-蛋白质相互作用 (PPI) 网络,协同表达网络和ceRNA网络.
- 使用DGIdb数据库调查潜在的药物相互作用.
主要成果:
- 在BE和EAC之间确定了92种常见的DEG和22种常见的SNP,富含皮肤和表皮发育.
- 最顶级的PPI网络模块包括SCEL,KRT6A和SPRR1A等基因.
- 构建了一个包含mRNA,miRNA和circRNA的ceRNA网络.
- 药物TD101与KRT6A基因发生相互作用.
结论:
- 这项研究揭示了新的候选基因,这些基因与BE和EAC之间的分子联系有关.
- 这些发现提供了潜在的诊断标志物和治疗点,以抑制BE的EAC发展.
- 进一步的研究可以利用这些发现来改善食道癌的临床管理.
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