植物抗菌剂:挑战与机遇
Tomayo I Berida1, Yemi A Adekunle2,3, Hannah Dada-Adegbola4
1Department of BioMolecular Sciences, Division of Pharmacognosy, University of Mississippi, University, MS, 38677, USA.
Heliyon
|May 28, 2024
概括
植物化合物显示出对抗抗菌素耐药性 (AMR) 的承诺. 然而,采购和理解它们如何工作等挑战阻碍了它们的临床使用,需要进一步的研究来开发有效的药物.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益增长的全球健康威胁.
- 自然产品,特别是来自植物的产品,提供了丰富的潜在抗菌剂来源.
- 目前有效的抗微生物药物主要来自真菌和细菌物种.
研究的目的:
- 审查阻碍植物衍生抗微生物化合物的临床应用的挑战.
- 批判性地检查这些药物的发现和开发管道中的障碍.
- 为推进植物性抗微生物药物对抗AMR提供见解.
主要方法:
- 关于植物衍生抗微生物化合物的综合文献综述.
- 分析采购,重新发现和药物动力学特性方面的挑战.
- 检查分子标和作用机制的知识差距.
主要成果:
- 有限的采购和重新发现代理物的风险是重要的障碍.
- 不理想的药物代谢和药理动力学 (DMPK) 特性阻碍了发展.
- 缺乏对分子点和作用机制的了解是一个关键问题.
结论:
- 应对已确定的挑战对于植物性抗微生物药物的成功临床开发至关重要.
- 需要进一步的研究来克服采购,DMPK和目标识别方面的障碍.
- 植物衍生化合物具有显著的潜力,作为对抗药物耐药性危机的新解决方案.
相关概念视频
Antibiotic Selection
53.2K
Overview
53.2K
Defenses Against Pathogens and Herbivores
23.6K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
23.6K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Combined Effects of Drugs: Synergism
3.9K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.9K
Plant Breeding and Biotechnology
18.9K
Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
18.9K
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K


