通过母系血统对代际糖尿病在雌性大鼠中的影响
Franciane Quintanilha Gallego1, Vinícius Soares Barco1, Yuri Karen Sinzato1
1Laboratory of Experimental Research on Gynecology and Obstetrics (UNIPEX), Course of Postgraduate on Tocogynecology, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo State, Brazil.
Heliyon
|May 28, 2024
概括
在大鼠中产妇高血糖引起后代 (F2和F3代) 的跨代糖尿病,影响葡萄糖代谢,生殖结果,并增加妊娠年龄新生儿的风险.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 孕产妇高血糖是妊娠不良后果的危险因素.
- 了解糖尿病的跨代影响对于公共卫生至关重要.
- 氧化应激和代谢失调是糖尿病的关键问题.
研究的目的:
- 研究母性高血糖症对斯普拉格-道利大鼠F2和F3代的跨代影响.
- 评估对氧化应激,脂质样本,血糖,胰腺β细胞和生殖结果的影响.
- 扩大对跨代糖尿病传播的知识.
主要方法:
- 在F0斯普拉格-道利大鼠中诱导糖尿病的新生儿链毒素 (STZ).
- F0和F1世代的交配产生F2后代用于分析.
- 通过口服葡萄糖耐受性测试 (OGTT),生化分析和胰腺形态评估F2生成.
- 在出生时对血糖和体重的F3代的评估.
主要成果:
- 患有糖尿病母亲的F2后代 (F2_D) 体重,甘油三和胰岛素阳性细胞较高,表明葡萄糖不耐受和胰岛素耐药性.
- 在F2_D怀孕中,胚胎损失显著增加 (84.33% 植入前,83.74% 植入后).
- 来自糖尿病血统的F3后代 (F3_D) 呈现高血糖症和更高的妊娠年龄大 (LGA) 新生儿发病率 (16.3%).
结论:
- 在F0大鼠中诱导新生儿糖尿病导致F2和F3代通过母系发生跨代代谢和生殖变化.
- 在整个怀孕期间严格的血糖控制对于减轻跨代糖尿病的影响至关重要.
- 这项研究强调了孕产妇高血糖症对子女健康的长期影响.
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