对报告和分析劳动持续时间质量的经验评估进行探索性审查
Emilienne Celetta1, Loukia M Spineli1, Valérie Avignon2
1Midwifery Research and Education Unit, Hannover Medical School, Hannover, Germany.
Birth (Berkeley, Calif.)
|May 28, 2024
概括
这次审查发现研究中的劳动持续时间的定义和统计方法不一致. 适用于时间到事件数据的生存分析在随机对照试验 (RCT) 和观察性研究中未得到充分利用.
科学领域:
- 产科和妇科 产科和妇科
- 生物统计学 生物统计学
- 临床研究方法论 临床研究方法论
背景情况:
- 在产科研究中,分娩时间是关键的结果.
- 现有的研究往往缺乏标准化的定义和统计方法.
- 本综述探讨了临床研究中劳动持续时间是如何测量和分析的.
研究的目的:
- 提供关于分娩开始和持续时间的定义的经验证据.
- 评估随机对照试验 (RCT) 和观察性研究中使用的统计方法和措施.
- 作为主要结果,识别报告劳动持续时间的不一致性.
主要方法:
- 在多个数据库中进行系统的电子文献搜索.
- 包括在1999年至2019年期间发表的英语,法语和德国的RCT和观察性研究.
- 提取关于劳动时间定义,统计指标和分析方法的数据.
主要成果:
- 很大一部分研究 (21.7%的RCT,23.8%的观察性研究) 没有定义分娩开始.
- 平均值和中位数分别是最常见的分娩持续时间指标.
- 经常使用双变量方法,特别是t测试,而多变量回归和时间到事件模型不太常见,特别是在RCT中.
结论:
- 劳动开始和阶段缺乏标准化的定义.
- 在劳动持续时间研究中使用的统计方法通常是次优的.
- 生存分析的不足利用限制了在产科研究中对时间到事件数据的适当分析.
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