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神经调节和肠-大脑轴:对于胃肠道和神经疾病的治疗机制和影响
Baha' Aljeradat1,2, Danisha Kumar1,3, Sulaiman Abdulmuizz1,4
1Global Neurosurgical Alliance, Tucson, AZ 85716, USA.
概括
神经调节技术在治疗肠-大脑轴障碍方面表现有前途. 通过向肠道微生物群和炎症,这些疗法为神经和胃肠道疾病提供了新的希望.
科学领域:
- 神经胃肠病学 神经胃肠病学
- 神经科学是一个神经科学.
- 微生物组研究的研究.
背景情况:
- 肠-大脑轴 (GBA) 是一个双向通信网络,连接胃肠道和中枢神经系统 (CNS).
- GBA的失调与各种神经和胃肠道疾病的病理生理学有关.
- 神经调节为这些疾病提供了潜在的治疗策略.
研究的目的:
- 审查神经调节技术在治疗与GBA相关的神经和胃肠道疾病中的有效性.
- 探索肠道微生物群,神经营养因子和细胞因子在GBA调节中的作用.
- 评估神经调节对IBS,IBD,GERD,PD,AD,ASD和神经精神疾病等疾病的影响.
主要方法:
- 包括PubMed,谷歌学者,科学网和科克兰图书馆在内的数据库的综合文献综述.
- 对研究神经调节对GBA组件和相关疾病的影响的研究分析.
- 综合关于神经调节在治疗胃肠道和神经疾病方面的疗效的证据.
主要成果:
- 神经调节可以通过调节肠道微生物群,神经营养因子和促炎细胞因子来积极影响GBA.
- 有证据表明,神经调节是有效的管理症状的刺激性肠综合征 (IBS),炎症性肠病 (IBD) 和胃食道逆流病 (GERD).
- 神经调节在治疗帕金森病 (PD),阿尔茨海默病 (AD),自闭症谱系障碍 (ASD) 和神经精神疾病方面显示出潜力.
结论:
- 神经调节是GBA相关疾病的重要治疗方法,提供了一种调整神经通路和减少炎症的方法.
- 这种方法有望改善胃肠道和神经系统疾病患者的生活质量.
- 对神经调节技术的进一步研究可能会在一系列复杂疾病的患者护理方面取得重大进展.
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