在斯普特尼克V (Gam-COVID-Vac) 疫苗接种后,SARS-CoV-2的幽默免疫力升
Alejandro Cornejo1, Christopher Franco2, Mariajose Rodriguez-Nuñez3
1Laboratorio de Bioquímica Celular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas 1020A, Venezuela.
Antibodies (Basel, Switzerland)
|May 28, 2024
概括
斯普特尼克V疫苗产生强大的抗体反应,对抗SARS-CoV-2尖端蛋白区域,包括受体结合域 (RBD). 这种免疫力,特别是在RBD之外的表位上,持续至少180天,证实了疫苗的疗效.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 通过引起免疫反应,SARS-CoV-2疫苗对于减轻COVID-19大流行至关重要.
- 了解针对特定病毒点的疫苗诱导抗体概况对于评估疗效至关重要.
研究的目的:
- 调查接种Sputnik V疫苗的个体对各种SARS-CoV-2尖端蛋白区域的抗体反应性.
- 为了将中和抗体 (NAb) 水平与抗体对随时间推移的尖端蛋白子单元的反应性相关联.
主要方法:
- 委内瑞拉Sputnik V疫苗接种个体的临床试验数据 (2020年12月 - 2021年7月).
- 使用针对受体结合域 (RBD) 的商业代用试验和减少斑块的中和试验,评估NAb活性.
- 检测针对核蛋白的抗体,以排除先前病毒暴露的影响.
主要成果:
- 对尖端 (S) 蛋白,特别是S1子单元和RBD.观察到高血清反应性.
- 在大流行前的血清中,S2亚单元的反应性较低,但交叉反应性更高.
- 在接种疫苗后,免疫力至少维持了180天.
结论:
- 斯普特尼克V疫苗诱导了对SARS-CoV-2的显著和持久免疫力.
- 抗体反应针对多个尖端蛋白表位体,包括RBD以外的表位体,有助于NAb活动.
- 这些发现支持斯普特尼克V的高效报告,并为未来的疫苗设计策略提供信息.
相关概念视频
01:51Vaccinations
44.4K
Overview
44.4K
01:23Immunological Memory
595
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
595
01:36Humoral Immune Responses
72.6K
Overview
72.6K
00:42Cross-reactivity
31.0K
Overview
31.0K
01:31Active versus Passive Immunity
630
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
630
02:50Conjugated Proteins
18.3K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.3K