在podocytopathies中针对nephrin的自身抗体
Felicitas E Hengel1, Silke Dehde1, Moritz Lassé1
1From the III. Department of Medicine (F.E.H., S.D., M.L., G.Z., L.S., A.S., O.K., F.G., R.L., L.M.M., E.H., M.M.R., N.M.T., T.B.H.) and the Departments of Medical Biometry and Epidemiology (H.O.P.), Pathology (T.Z., T.W.), Pediatric Nephrology (J.O.), and Obstetrics and Fetal Medicine (A.D.), Hamburg Center for Kidney Health (F.E.H., S.D., M.L., G.Z., L.S., A.S., O.K., F.G., R.L., L.M.M., J.O., E.H., M.M.R., N.M.T., T.B.H.), and the Hamburg Center for Translational Immunology (N.M.T., T.B.H.), University Medical Center Hamburg-Eppendorf, Hamburg, and the Center for Pediatrics and Adolescent Medicine, University Hospital Heidelberg, Heidelberg (F.S.) - all in Germany; the Department of Biomedicine, Aarhus University, Aarhus, Denmark (F.D., A.M.B., M.M.R.); the Department of Precision and Regenerative Medicine and Ionian Area, Nephrology, Dialysis, and Transplantation Unit, University of Bari Aldo Moro, Bari (A.M., P.P., L.G.), and the Division of Nephrology, Bambino Gesù Children's Hospital, IRCCS, Rome (M.C., F.E., M.V.) - both in Italy; INSERM, Unité Mixte de Recherche S 1155, Sorbonne Université (H.D., P.R.), and the Pediatric Nephrology Department, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris (C.D., J.H.), Paris, and the Division of Nephrology, Centre Hospitalier du Mans, Le Mans (P.R.) - all in France; the Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, and the Department of Pediatrics, Ohio State University College of Medicine - both in Columbus (W.E.S.); the Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School - both in Boston (A.W.); and the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (N.A.).
针对氨酸的自身抗体在最小变化疾病和异常性性综合征中很常见,作为疾病活动的标记物,并通过破坏细胞引起性综合征.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 最小变化疾病 (MCD) 和异常性性综合征 (INS) 是免疫介导的细胞病,导致性综合征.
- 在这些条件下对尼弗林的自身抗体的作用以前是不清楚的.
研究的目的:
- 调查抗尼弗林自身抗体在成人和儿童性综合征中的流行率和作用.
- 建立抗尼弗林自身抗体与疾病活动和发病之间的联系.
主要方法:
- 一项多中心研究分析了539名患有各种淋巴细胞疾病的患者和117名对照者的抗尼弗林自身抗体.
- 一种实验性小鼠模型是通过用重组小鼠内素进行活性免疫开发出来的.
主要成果:
- 在44%的成人MCD患者和52%的儿科INS患者中检测到抗尼弗林自身抗体.
- 抗体水平与疾病活性相关,实验性免疫在小鼠中诱导了瘤综合征和 podocyte 损伤.
结论:
- 循环抗尼弗林自身抗体在MCD和INS中普遍存在,并作为疾病活动的标记物.
- 这些自身抗体通过裂口隔膜结合,导致细胞功能障碍和脏综合征的发病.
相关概念视频
Nephrons
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...


