基于催化剂的度法用于半量化含硫化合物和ibuprofen中的痕量
Judey T DaRos1, Miho Naruse1, Jasmyne M Mendoza1
1Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
The Journal of organic chemistry
|May 28, 2024
概括
这项研究表明,计方法可以检测材料中的微量和,即使与硫结合. 大多数硫化合物不会干扰,使其成为可靠的量化技术.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 对合成材料来说,微量的检测至关重要.
- 一种使用resorufin 乙烯转换的度法存在,但其对硫干扰的易感性尚不清楚.
研究的目的:
- 系统地研究硫化合物的干扰作用,采用量化度法.
- 评估该方法适用于与硫基材料结合的和像布洛芬这样的制药样品中的的适用性.
主要方法:
- 采用了以催化为基础的度测定方法.
- 各种硫化合物 (硫尿素,硫化物,硫醇,硫酸盐) 进行了干扰测试.
- 评估了该方法的性能,用于检测硫基清洁树脂和布洛芬样本中的.
- 与诱导合等离子体质谱法 (ICP-MS) 进行了比较.
主要成果:
- 发现氨酸干扰了的度量化量化.
- 硫化物,硫醇和硫酸盐并没有干扰该方法.
- 度法成功检测到与硫基清洁剂树脂结合的.
- 该方法在检测ibuprofen中的微量拉方面表现优于ICP-MS.
结论:
- 度法对大多数常见的硫化合物具有稳定性,氨酸是主要的例外.
- 这种方法提供了一种快速,廉价和有效的替代方法,用于在各种矩阵中半量化痕迹,包括像布洛芬这样具有挑战性的样品.
- 该技术适用于检测在含硫材料上固定不动的.
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