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在早期引入花生以预防过敏后,对青春期的随访
George Du Toit1,2,3, Michelle F Huffaker4, Suzana Radulovic1,2,3
1Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London.
NEJM evidence
|May 28, 2024
概括
在婴儿期到5岁的早期花生消费可以防止花生过敏的发展,并建立长期的青春期的耐受性. 这种早期暴露表明了预防食物过敏的长期战略.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 儿童营养学 儿童营养学
背景情况:
- 在一项随机试验中,婴儿食用花生可以预防花生过敏.
- 这种保护作用在避免花生一年后仍然存在.
- 目前的研究评估了144个月的长期耐受性.
研究的目的:
- 为了检查早期消费引起的花生耐受性的持久性.
- 为了确定耐受性是否持续到青春期,尽管随后避免了.
主要方法:
- 从先前的随机化花生消费试验中对参与者的随访.
- 在144个月时评估花生过敏率.
- 对过敏原特异性免疫球蛋白水平 (IgE,IgG4) 的分析.
主要成果:
- 在144个月的年龄 (P<0.001) 早期消费组 (4.4%) 和避免组 (15.4%) 中,花生过敏的发生率明显较低.
- 两组参与者都报告说,在72岁至144个月之间,他们长期避免吃花生.
- 在消费组中观察到较低的Ara h2特异性IgE和较高的花生特异性IgG4水平.
结论:
- 婴儿花生消费给青春期带来持久的耐受性,无论后来的摄入量如何.
- 早期和持续接触花生是一种可行的长期预防食物过敏的策略.
- 这项研究突出了食物过敏中耐久耐受性诱导的潜力.
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