怀孕期间暴露于宏化物和自发流产的风险:基于人口的回顾性队列研究
Shani Hegger1, Amalia Levy1, Gideon Koren2
1Department of Epidemiology, Biostatistics, and Community Health Sciences, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Journal of clinical pharmacology
|May 28, 2024
概括
这项研究发现,在怀孕期间暴露于类抗生素后,自发流产的风险没有增加. 在这个基于人口的大群体中,在头三个月内使用麦克罗利德与不良妊娠结果无关.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 之前关于类抗生素暴露和自发流产风险的研究产生了相互矛盾的结果.
- 了解孕期宏酸盐的安全性对于临床决策至关重要.
研究的目的:
- 调查妊娠期间类物质暴露与自发流产风险之间的关联.
- 为了澄清在怀孕早期使用宏类药物的安全性.
主要方法:
- 一个基于人口的回顾性队列研究,利用链接的健康数据库.
- 包括65,457例怀孕,分析了类物质暴露和自发流产的结果.
- 多变量考克斯回归分析调整了混因子,计算了调整的危险比率 (HR) 和95%信心区间 (CI).
主要成果:
- 在1.26%的怀孕中发生了宏化物暴露;9.9%导致了自发流产.
- 在化物暴露和自发流产之间没有发现统计学上显著的关联 (调整HR为1.00,95%CI为0.77-1.31).
- 没有观察到宏类药物暴露和自发流产风险之间的剂量反应关系.
结论:
- 这项研究没有发现证据表明,在第一季度暴露于宏化物后,自发流产的风险增加.
- 关于怀孕中自发流产风险,宏类抗生素似乎是安全的.
- 这些发现有助于为孕妇使用抗生素制定基于证据的指导方针.
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